Postgraduate ****************************************************************************************** * Postgraduate study programs ****************************************************************************************** Supervisors: Prof. Soňa Nevšímalová, M.D., DSc. Prof. Jan Roth M.D., PhD. Prof. Evžen Růžička, M.D., DSc. Prof. Karel Šonka, M.D., DSc. Assoc. Prof. Eva Havrdová, M.D, PhD. Assoc. Prof. Robert Jech M.D., PhD. David Kemlink, M.D., Ph.D. Tomáš Kalinčík, M.D., Ph.D. Hana Brožová, M.D., Ph.D. Iva Příhodová, M.D., Ph.D. MUDr. Jiří Klempíř, Ph.D. Jitka Bušková, M.D., Ph.D. General PGS themes: • Disorders of sleep and wakfulness in childhood and adulthood (clinical polysomnographic, genetic correlations • Exogenic factorc with impact on the quality of sleep (detection of changes in sleep macr microstructure). Civilisation diseases and quality of sleep. • Neurodevelopmental problems and neurometabolic disorders of childhood Annotation of themes: PGS research projects come out of the supervisor´s long-term study of the problems of slee clinical, neurophysiological and genetic points of view. Research is centered both on prim sleep and waking but also on secondary sleep disorders concomitant to a number of neurolog Research efforts are aimed also at the growing incidence of civilisation diseases related sleep quality and quantity. Other options for research projects are in the field of paedia - a spectrum of developmental, metabolic and degenerative diseases; projects orientated to genetic and neurophysiological problems and also toward new diagnostic and therapeutic met General PGS themes: • Clinical, functional and morphometric parameter correlations in Huntington´s disease • Non-motor manifestations of Huntington´s disease • Huntington´s disease: genetic testing impact on patients, persons at risk and caregivers Annotation of themes: PGS research projects based upon experience gathered at the Extrapyramidal Disease Centre to the diagnostic, therapeutical and basic research problems related to Huntington´s disea maintains close cooperation with the Institute of Medical Genetics, with the Department of other institutions. The Center is part of the European Huntington´s Disease Network and ta its activities. Available in the Centre´s database are the results of genetic tests, struc data and results of auxiliary diagnostic methods including scales for the quantification o ´ motor and neuropsychological disorders. The database will help in the choidce of patient study cooperation. For clinical research purposes, use will also be made of specific MRI m neuropsychological testing by psychologists experienced in handling patients with Huntingt speech therapists´ experience in the management of speech and swallowing disorders etc. General PGS themes: • Study of motor and non-motor effects of deep brain stimulation in extrapyramidal movemen • Analysis of gait and other inborn and acquired movement stereotypes and their disorders • Selection, phenotypic characteristics and gene analysis of clinical subpopulations of in extrapyramidal diseases (essential tremor, juvenile Parkinson´s disease, Tourette syndro • Neuropharmacological mechanisms and therapeutic studies in extrapyramidal movement disor Annotation of themes: PGS research projects are inspired by the clinical work done by the Extrapyramidal Disease and hyperkinetic movement disorders in Parkinson´s disease and other extrapyramidal affect as model examples for the study of movement control mechanisms in man. Clinimetric, functi kinesiological, electrophysiological and neuropsychological methods are made use of for th of motor and non-motor manifestations of the disease. They are also applied for studying t of pharmacological and non-pharmacological therapeutic procedures (including functional ne operations and physiotherapeutical techniques). Clinical-epidemiological and genetic studi for the purpose of learning more about the aetiopathogenesis of each of the pathological e General PSG themes: • Sleep-related breathing disorders • Sleep and waking disorders in neurological diseases • Pathophysiology of sleep and waking disorders • Social aspects of sleep and waking disorders Annotation of themes: The themes are based on the clinical experience gathered by staff members of the Centre fo Waking disorders of the VFN General Teaching Hospital and CU 1st Medical Faculty. Sleep-re disorders are very frequent, occurring either alone or in combination with concomitant dis rate of sleep disorders underlying neurological diseases is quite significant, which is wh foreign neurological centres worldwide devote a great deal of efforts to these inter-relat more about them can help expand our knowledge of their pathophysiology as well as improve ´quality of life. Research at the Department of Neurology, CU 1st MF, benefits from a well laboratory, a large number of standardly examined patients, and from cooperation with rela as remote disciplines. While the social aspects of sleep and, in particular, waking disord intensive study worldwide, little attention has been paid to them in the CR so far. Hence, line of research as useful and prospective science-wise. General PGS themes: • Immunosuppressive methods in the treatment of multiple sclerosis including its malignant • Neurorehabilitation for motor function control in MS patients Annotation of themes: 1.Tests for the safety and efficacy (clinical, immunological, MRI) of combination methods immunosuppressives in MS management. Introduction of intensive immunoablation method in of malignant MS. Detection of patients responding to treatment or having risk factors fo prognosis with the aid of molecular - genetic methods in cooperation with KDDL laborator P.Martásek, DrSc.). 2.Monitoring the effect of modern neurorehabilitation methods in MS management (including - in cooperation with PhDr. K. Řasová, PhD. 3.Neuropsychology of MS Note for anyone interested: priority is given to candidates who frequented the Centre for Disorder already during the undergraduate studies and who participated both in clinical in in scientific projects. General PGS themes: • Pathophysiological mechanisms of movement control in extrapyramidal diseases • Functional magnetic resonance - new tasks and their application in neurology and neurosu Annotation of themes:  Research is centered on the effects of deep brain stimulation, on the analysis of the phys mechanisms of voluntary movement control and on the pathophysiological mechanisms of abnor patterns (dystonia, myoclonus, tremor, Parkinsonism), white matter MR tractography, multim potentials, unit brain activity recording, electroencephalography and transcranial magneti General PGS themes: • Restless leg syndrome - clinical and genetic aspects • Neurophysiological methods for sleep testing - application of polysomnography and actigr • Genetic association and linkage studies - practical uses of statistical genetics in neur disorders Annotation of themes: Research is mainly concerned with sleep disorder studies at the Centre for Sleep and Wakin in particular: the restless leg syndrome. Work in this field is centered on the clinical a syndrome, making good use of especially the monitoring capacity of the sleep laboratory. I with counterparts in Munich, basic research is in progress of its genetic mechanisms with capacity platforms. The association study basic procedures for the detection and verificat of human genome polymorphism can also be applied to other multifactorial diseases with sig components; as for sleep disorders, research into narcolepsy is now in progress. General PGS themes: • Multiple sclerosis: prediction and prognosis, neuropsychology, pharmacoeconomy and genet Annotation of themes: The focus of the research is to investigate clinical and paraclinical predictors of course sclerosis and the efficacy of treatment. Other researched aspects of multiple sclerosis co and safety of combined immunomodulatory and immunosuppressive therapy, osteoporosis, immun pharmacoeconomics and neurophysiology. Training in biostatistics and research methods is i research projects. General PGS themes: • Sleep disorders in childhood and their health consequences • Abnormal movements related to sleep • Sleep disorders in child neuropsychiatric disorders Annotation of themes: Research topics are aimed at child sleep disorders which can influence the quality of life movements related to sleep, obstructive sleep apnoea, parasomnias). Sleep assessment can b evaluation of polysomnographic characteristics including sleep mictrostructure. Questionna actigraphy represent other possibilities of sleep investigation. Another topic is an incidence of sleep disorders in child neuropsychiatric disorders (atte hyperactivity disorder, Tourette syndrome), possible mutual relationship and impact on cli symptomatology.